Two sample MR report
SRSF2_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.3944721 | 0.9072212 | 0.7388882 |
| Weighted median | 3 | -0.2527763 | 0.0566945 | 0.0000083 |
| Inverse variance weighted | 3 | -0.2488480 | 0.0428709 | 0.0000000 |
| Simple mode | 3 | -0.2567834 | 0.0680633 | 0.0636255 |
| Weighted mode | 3 | -0.2564238 | 0.0630983 | 0.0555531 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0649215 | 1 | 0.7988799 |
| Inverse variance weighted | 0.0907448 | 2 | 0.9556416 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0619746 | 0.3856633 | 0.8985648 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.51e-05 | 1e-07 | TRUE | 0.4926967 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
